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Divergent Evolution of Early Terrestrial Fungi Reveals the Evolution of Mucormycosis Pathogenicity Factors.

Authors :
Wang, Yan
Chang, Ying
Ortañez, Jericho
Peña, Jesús F
Carter-House, Derreck
Reynolds, Nicole K
Smith, Matthew E
Benny, Gerald
Mondo, Stephen J
Salamov, Asaf
Lipzen, Anna
Pangilinan, Jasmyn
Guo, Jie
LaButti, Kurt
Andreopolous, William
Tritt, Andrew
Keymanesh, Keykhosrow
Yan, Mi
Barry, Kerrie
Grigoriev, Igor V
Source :
Genome Biology & Evolution; Apr2023, Vol. 15 Issue 4, p1-19, 19p
Publication Year :
2023

Abstract

Fungi have evolved over millions of years and their species diversity is predicted to be the second largest on the earth. Fungi have cross-kingdom interactions with many organisms that have mutually shaped their evolutionary trajectories. Zygomycete fungi hold a pivotal position in the fungal tree of life and provide important perspectives on the early evolution of fungi from aquatic to terrestrial environments. Phylogenomic analyses have found that zygomycete fungi diversified into two separate clades, the Mucoromycota which are frequently associated with plants and Zoopagomycota that are commonly animal-associated fungi. Genetic elements that contributed to the fitness and divergence of these lineages may have been shaped by the varied interactions these fungi have had with plants, animals, bacteria, and other microbes. To investigate this, we performed comparative genomic analyses of the two clades of zygomycetes in the context of Kingdom Fungi, benefiting from our generation of a new collection of zygomycete genomes, including nine produced for this study. We identified lineage-specific genomic content that may contribute to the disparate biology observed in these zygomycetes. Our findings include the discovery of undescribed diversity in CotH, a Mucormycosis pathogenicity factor, which was found in a broad set of zygomycetes. Reconciliation analysis identified multiple duplication events and an expansion of CotH copies throughout the Mucoromycotina, Mortierellomycotina, Neocallimastigomycota, and Basidiobolus lineages. A kingdom-level phylogenomic analysis also identified new evolutionary relationships within the subphyla of Mucoromycota and Zoopagomycota, including supporting the sister-clade relationship between Glomeromycotina and Mortierellomycotina and the placement of Basidiobolus as sister to other Zoopagomycota lineages. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17596653
Volume :
15
Issue :
4
Database :
Complementary Index
Journal :
Genome Biology & Evolution
Publication Type :
Academic Journal
Accession number :
163071354
Full Text :
https://doi.org/10.1093/gbe/evad046