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Clinical Characterization and Outcomes of Patients with Hypercreatinemia Affected by COVID-19.
- Source :
- Healthcare (2227-9032); Apr2023, Vol. 11 Issue 7, p944, 14p
- Publication Year :
- 2023
-
Abstract
- The present study evaluated the clinical presentation and outcome of COVID-19 patients with underlying hypercreatinemia at the time of hospitalization. A retrospective observational study was conducted from the 23rd of March 2020 to the 15th of April 2021 in 1668 patients confirmed positive for COVID-19 in the Chest Disease Hospital in Srinagar, India. The results of the present study revealed that out of 1668 patients, 339 with hypercreatinemia had significantly higher rates of admission to the intensive care unit (ICU), severe manifestations of the disease, need for mechanical ventilation, and all-cause mortality. Multivariable analysis revealed that age, elevated creatinine concentrations, IL-1, D-Dimer, and Hs-Crp were independent risk factors for in-hospital mortality. After adjusted analysis, the association of creatinine levels remained strongly predictive of all-cause, in-hospital mortality (HR-5.34; CI-4.89–8.17; p ≤ 0.001). The amelioration of kidney function may be an effective method for achieving creatinemic targets and, henceforth, might be beneficial for improving outcomes in patients with COVID-19. [ABSTRACT FROM AUTHOR]
- Subjects :
- KIDNEY physiology
HOSPITALS
RESEARCH
INTENSIVE care units
C-reactive protein
PHYSICAL diagnosis
COVID-19
KIDNEY function tests
CONFIDENCE intervals
KIDNEY failure
MULTIVARIATE analysis
FERRITIN
RETROSPECTIVE studies
MANN Whitney U Test
TREATMENT effectiveness
ARTIFICIAL respiration
HOSPITAL mortality
SURVIVAL rate
COMPARATIVE studies
HOSPITAL care
EPIDEMICS
DESCRIPTIVE statistics
CHI-squared test
KAPLAN-Meier estimator
DATA analysis software
CREATININE
LONGITUDINAL method
LYMPHOCYTE count
PROPORTIONAL hazards models
Subjects
Details
- Language :
- English
- ISSN :
- 22279032
- Volume :
- 11
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Healthcare (2227-9032)
- Publication Type :
- Academic Journal
- Accession number :
- 163041590
- Full Text :
- https://doi.org/10.3390/healthcare11070944