Back to Search
Start Over
Ascending aorta dilatation reduces the influence of elevated pulse pressure on left ventricular hypertrophy: findings from a Chinese elderly hypertensive population.
- Source :
- Journal of Geriatric Cardiology; 2023, Vol. 20 Issue 2, p100-108, 9p
- Publication Year :
- 2023
-
Abstract
- OBJECTIVE: To determine the role of ascending aorta dilatation in the relationship between pulse pressure (PP) and left ventricular (LV) hypertrophy. METHODS: A total of 1556 Chinese elderly hypertensive patients were retrospectively studied. Transthoracic echocardiography was used to obtain the aortic and cardiac structure measurements. In addition, brachial blood pressure was measured, and total arterial compliance, systemic vascular resistance, arterial elastance, and end-systolic LV elastance were calculated. The participants were divided into four groups according to the status of ascending aortic diameter and PP. RESULTS: LV mass index increased in succession in the four groups, i.e., the group with the normal aorta and lower PP, with the normal aorta and higher PP, with aortic dilatation and lower PP, and with aortic dilatation and higher PP (Ptrend < 0.001). Total arterial compliance-1, arterial elastance, and end-systolic LV elastance were slightly higher in the individuals with normal aorta compared to those with aortic dilatation, regardless of PP being lower or higher (P < 0.01). Compared to the group with the normal aorta and lower PP, individuals with aortic dilatation had a significantly increased multivariable adjusted risk of LV hypertrophy, and higher PP further exacerbated this risk [aortic dilatation with lower PP (OR = 1.75, 95% CI: 1.01-3.04) and aortic dilatation with higher PP (OR = 3.42, 95% CI: 2.03-5.77)]. In the relation between PP and LV mass index (ß = 0.095, P < 0.001), -41.3% of the total effect was attributable to mediation by ascending aortic diameter (P < 0.0001). CONCLUSIONS: In Chinese elderly patients with hypertension, ascending aorta dilatation could reduce the influence of elevated PP on LV hypertrophy. [ABSTRACT FROM AUTHOR]
- Subjects :
- BLOOD pressure
CONFIDENCE intervals
ANALYSIS of variance
LEFT ventricular hypertrophy
MULTIVARIATE analysis
RETROSPECTIVE studies
RISK assessment
T-test (Statistics)
PEARSON correlation (Statistics)
DESCRIPTIVE statistics
CHI-squared test
AORTA
DATA analysis software
ODDS ratio
LOGISTIC regression analysis
HEMODYNAMICS
HYPERTENSION in old age
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 16715411
- Volume :
- 20
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Geriatric Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 162932869
- Full Text :
- https://doi.org/10.26599/1671-5411.2023.02.005