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Chamomile and Urtica dioica extracts improve immunological and histological alterations associated with polycystic ovarian syndrome in DHEA -induced mice.
- Source :
- BMC Complementary Medicine & Therapies; 4/3/2023, Vol. 23 Issue 1, p1-12, 12p, 1 Color Photograph, 1 Chart, 5 Graphs
- Publication Year :
- 2023
-
Abstract
- Background: One of the novel mechanisms in the pathogenesis of Polycystic ovary syndrome (PCOS) is low-grade chronic inflammation. Chamomile (Matricaria recutita L.) and Nettle (Urtica dioica), with phytoestrogenic and antioxidant properties, are traditionally used to treat gynecological diseases. This study investigated the immune-modulating effects of these two plants. Methods: Following the induction of PCOS by subcutaneous injection (SC) of Dehydroepiandrosterone (DHEA) in BALB / C mice. Mice were treated in five groups: Sham, PCOS, PCOS + Chamomile, PCOS + Nettle, and PCOS + Chamomile and Nettle for 21 days. Ovarian morphology, blood antioxidant capacity, the abundance of Treg cells, and expression of matrix metalloproteinase-9 (MMP-9), transforming growth factor-ß (TGF-ß), cyclooxygenase-2 genes (COX-2), and tumor necrosis factor-alpha (TNF-α) were measured. Results: Folliculogenesis, Cystic follicles, and corpus luteum improved in the treatment groups (P < 0. 05). Treg cells in the DHEA group were significantly reduced compared to the Sham group (P < 0. 01). However, this decrease was not corrected in treatment groups (P > 0. 05). Total serum antioxidant capacity was significantly increased in the treatment group of Nettle and Chamomile + Nettle (P < 0. 05). The expression of MMP9 and TGFβ genes in the PCOS group was significantly higher than the Sham group (P < 0. 05), which the expression of MMP9 was corrected by treatment with Chamomile + Nettle extract (P < 0. 05). Conclusion: Chamomile and Nettle extract may be an effective supplement in improving the histological and immunological changes of PCOS. However, more research is needed to confirm its effectiveness in humans. [ABSTRACT FROM AUTHOR]
- Subjects :
- INFLAMMATION prevention
STINGING nettle
OVARIES
TRANSFORMING growth factors-beta
HUMAN reproduction
FASTING
STATISTICS
BIOMARKERS
ROMAN chamomile
POLYCYSTIC ovary syndrome
COMBINATION drug therapy
ANIMAL experimentation
ONE-way analysis of variance
ANTI-inflammatory agents
DEHYDROEPIANDROSTERONE
IMMUNOMODULATORS
IMMUNE system
ANTIOXIDANTS
REGULATORY T cells
BLOOD collection
BLOOD sugar
HYPOGLYCEMIC agents
GERMAN chamomile
MATRIX metalloproteinases
GENE expression
COMPARATIVE studies
RESEARCH funding
DESCRIPTIVE statistics
TUMOR necrosis factors
HISTOLOGICAL techniques
OVARIAN follicle
PLANT extracts
OXIDOREDUCTASES
DATA analysis software
DATA analysis
MICE
PHYTOESTROGENS
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 26627671
- Volume :
- 23
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Complementary Medicine & Therapies
- Publication Type :
- Academic Journal
- Accession number :
- 162870958
- Full Text :
- https://doi.org/10.1186/s12906-023-03936-7