Back to Search Start Over

Roles of Hydrogen, Halogen Bonding and Aromatic Stacking in a Series of Isophthalamides.

Authors :
Osman, Islam Ali
McKee, Vickie
Jelsch, Christian
Gallagher, John F.
Source :
Symmetry (20738994); Mar2023, Vol. 15 Issue 3, p738, 22p
Publication Year :
2023

Abstract

Highlights: What are the main findings? A complete series of structures differing from H-DIP to I-DIP. Rationalizing the Cl-DIP structure (Z' = 3) with two distinct conformations. The great wall of bromines at the 2D sheet interfaces in Br-DIP. What is the implication of the main finding? Comparison of organic halogenated materials Br-DIP and the inorganic PbBr<subscript>2</subscript>, CuBr<subscript>2</subscript>. The unusual synthon formed by the tightly bound hydrate in I-DIP•½(H<subscript>2</subscript>O). Simple Summary: Crystal and modelled structures of five N<superscript>1</superscript>,N<superscript>3</superscript>-di(5-X-pyridin-2-yl)isophthalamides (X = H, F to I) as (X-DIP) are reported. The roles that their molecular conformations and interactions play in solid-state aggregation are assessed. Cl-DIP (Z' = 3) exhibits both syn/anti and anti/anti molecular conformations in 2:1 ratio. The hydrogen bonding hierarchy and sheet formation in Br-DIP induces the formation of a bromine-rich environment manifesting as a 'wall of bromine atoms' at the sheet interfaces. The hydrate in I-DIP•½(H<subscript>2</subscript>O) forms a rare synthon. The synthesis and spectroscopic characterisation of six bis(5-X-pyridine-2-yl)isophthalamides (X = H, F, Br, Cl, I, NO<subscript>2</subscript>) are reported, together with five crystal structure analyses (for X = H, F to I). The isophthalamides span a range of conformations as syn/anti (H-DIP; I-DIP), anti/anti- (F-DIP; Br-DIP) and with both present in ratio 2:1 in Cl-DIP. The essentially isostructural F-DIP and Br-DIP molecules (using strong amide...amide interactions) aggregate into 2D molecular sheets that align with either F/H or Br atoms at the sheet surfaces (interfaces), respectively. Sheets are linked by weak C-H⋯F contacts in F-DIP and by Br⋯Br halogen bonding interactions as a 'wall of bromines' at the Br atom rich interfaces in Br-DIP. Cl-DIP is an unusual crystal structure incorporating both syn/anti and anti/anti molecular conformations in the asymmetric unit (Z' = 3). The I-DIP•½(H<subscript>2</subscript>O) hemihydrate structure has a water molecule residing on a twofold axis between two I-DIPs and has hydrogen and N⋯I (N<subscript>c</subscript> = 0.88) halogen bonding. The hydrate is central to an unusual synthon and involved in six hydrogen bonding interactions/contacts. Contact enrichment analysis on the Hirshfeld surface demonstrates that F-DIP, Cl-DIP and Br-DIP have especially over-represented halogen···halogen interactions. With the F-DIP, Cl-DIP and Br-DIP molecules having an elongated skeleton, the formation of layers of halogen atoms in planes perpendicular to the long unit cell axis occurs in the crystal packings. All six DIPs were analysed by ab initio calculations and conformational analysis; comparisons are made between their minimized structures and the five crystal structures. In addition, physicochemical properties are compared and assessed. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20738994
Volume :
15
Issue :
3
Database :
Complementary Index
Journal :
Symmetry (20738994)
Publication Type :
Academic Journal
Accession number :
162834550
Full Text :
https://doi.org/10.3390/sym15030738