Back to Search
Start Over
F 1 ·F o ATP Synthase/ATPase: Contemporary View on Unidirectional Catalysis.
- Source :
- International Journal of Molecular Sciences; Mar2023, Vol. 24 Issue 6, p5417, 20p
- Publication Year :
- 2023
-
Abstract
- F<subscript>1</subscript>·F<subscript>o</subscript>-ATP synthases/ATPases (F<subscript>1</subscript>·F<subscript>o</subscript>) are molecular machines that couple either ATP synthesis from ADP and phosphate or ATP hydrolysis to the consumption or production of a transmembrane electrochemical gradient of protons. Currently, in view of the spread of drug-resistant disease-causing strains, there is an increasing interest in F<subscript>1</subscript>·F<subscript>o</subscript> as new targets for antimicrobial drugs, in particular, anti-tuberculosis drugs, and inhibitors of these membrane proteins are being considered in this capacity. However, the specific drug search is hampered by the complex mechanism of regulation of F<subscript>1</subscript>·F<subscript>o</subscript> in bacteria, in particular, in mycobacteria: the enzyme efficiently synthesizes ATP, but is not capable of ATP hydrolysis. In this review, we consider the current state of the problem of "unidirectional" F<subscript>1</subscript>·F<subscript>o</subscript> catalysis found in a wide range of bacterial F<subscript>1</subscript>·F<subscript>o</subscript> and enzymes from other organisms, the understanding of which will be useful for developing a strategy for the search for new drugs that selectively disrupt the energy production of bacterial cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16616596
- Volume :
- 24
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 162813058
- Full Text :
- https://doi.org/10.3390/ijms24065417