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Disease-Modifying Adjunctive Therapy of Osteopenia and Osteoporosis with a Multimineral Marine Extract, LithoLexal ® Bone.
- Source :
- Osteology; Mar2023, Vol. 3 Issue 1, p22-32, 11p
- Publication Year :
- 2023
-
Abstract
- There is evidence to suggest that restoration of major/rare biominerals by supplementation can produce osteogenic and anti-resorptive effects in humans. LithoLexal<superscript>®</superscript> is a natural extract harvested from a marine alga, Lithothamnion sp., with a porous microstructure and multimolecular composition rich in calcium (32% w/w) and magnesium (2.2% w/w) together with ~72 trace bioelements. In vitro, LithoLexal<superscript>®</superscript> demonstrated cellular-level osteogenic efficacy through enhancing the maturation and activity of pre-osteoblasts. This extract also expressed the ability to suppress osteoclastogenesis by downregulating the pro-resorptive cytokines TNF-α and IL-1β and the master regulator of inflammation NF-κB. Parathyroid hormone inhibition of parathyroid hormone secretion is another bioactivity of LithoLexal<superscript>®</superscript> Bone reported with both short- and long-term administration at a longer duration and higher magnitude than what calcium carbonate could induce. Due to these bioactivities that affect pathogenetic factors of osteoporosis, LithoLexal<superscript>®</superscript> Bone is referred to as a disease-modifying adjunctive therapy (DMAT). In postmenopausal animal models, LithoLexal<superscript>®</superscript> monotherapy preserved bone mineral density, microarchitecture, and biomechanical properties, while calcium carbonate failed to produce significant outcomes. The pro-resorptive effect of a high-fat diet was also efficiently counteracted in vivo by supplementary LithoLexal<superscript>®</superscript>. A large clinical trial on postmenopausal women verified the mitigating effects of LithoLexal<superscript>®</superscript> Bone on bone resorption and turnover rate. The characteristic composition of LithoLexal<superscript>®</superscript> together with its lattice microstructure are suggested to underlie its in vivo bioactivities. In conclusion, adjunctive therapy with LithoLexal<superscript>®</superscript> Bone is an attractive option for clinical prevention and treatment of osteopenia/osteoporosis. [ABSTRACT FROM AUTHOR]
- Subjects :
- OSTEOPENIA
OSTEOPOROSIS
EXTRACTS
MARINE algae
BONE diseases
TREATMENT effectiveness
Subjects
Details
- Language :
- English
- ISSN :
- 26734036
- Volume :
- 3
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Osteology
- Publication Type :
- Academic Journal
- Accession number :
- 162785202
- Full Text :
- https://doi.org/10.3390/osteology3010004