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Activity Sensing of Coagulation and Fibrinolytic Proteases.

Authors :
Sondag, Daan
Verhoeven, Stijn
Löwik, Dennis W. P. M.
van Geffen, Mark
Veer, Cornelis van't
van Heerde, Waander L.
Boltje, Thomas J.
Rutjes, Floris P. J. T.
Source :
Chemistry - A European Journal; 3/28/2023, Vol. 29 Issue 18, p1-16, 16p
Publication Year :
2023

Abstract

The blood coagulation cascade is a complex physiological process involving the action of multiple coupled enzymes, cofactors, and substrates, ultimately leading to clot formation. Serine proteases have a crucial role, and aberrations in their activity can lead to life‐threatening bleeding disorders and thrombosis. This review summarizes the essential proteases involved in blood coagulation and fibrinolysis, the endogenous peptide sequences they recognize and hydrolyze, and synthetic peptide probes based on these sequences to measure their activity. The information in this review can contribute to developing novel anticoagulant therapies and specific substrates for point‐of‐care diagnosis of coagulation pathologies. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09476539
Volume :
29
Issue :
18
Database :
Complementary Index
Journal :
Chemistry - A European Journal
Publication Type :
Academic Journal
Accession number :
162757628
Full Text :
https://doi.org/10.1002/chem.202203473