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Severe COVID-19 versus multisystem inflammatory syndrome: comparing two critical outcomes of SARS-CoV-2 infection.
- Source :
- European Respiratory Review; Mar2023, Vol. 32 Issue 167, p1-20, 20p
- Publication Year :
- 2023
-
Abstract
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with diverse host response immunodynamics and variable inflammatory manifestations. Several immune-modulating risk factors can contribute to a more severe coronavirus disease 2019 (COVID-19) course with increased morbidity and mortality. The comparatively rare post-infectious multisystem inflammatory syndrome (MIS) can develop in formerly healthy individuals, with accelerated progression to life-threatening illness. A common trajectory of immune dysregulation forms a continuum of the COVID-19 spectrum and MIS; however, severity of COVID-19 or the development of MIS is dependent on distinct aetiological factors that produce variable host inflammatory responses to infection with different spatiotemporal manifestations, a comprehensive understanding of which is necessary to set better targeted therapeutic and preventative strategies for both. [ABSTRACT FROM AUTHOR]
- Subjects :
- COVID-19 pandemic
MORTALITY
PUBLIC health
HEALTH outcome assessment
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 09059180
- Volume :
- 32
- Issue :
- 167
- Database :
- Complementary Index
- Journal :
- European Respiratory Review
- Publication Type :
- Academic Journal
- Accession number :
- 162661272
- Full Text :
- https://doi.org/10.1183/16000617.0197-2022