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Cross-Serotype Neutralization of Dengue Virus in Aotus nancymae Monkeys.
- Source :
- Journal of Infectious Diseases; 3/15/2005, Vol. 191 Issue 6, p1000-1004, 5p
- Publication Year :
- 2005
-
Abstract
- Previously, we observed that serum from humans immune to dengue serotype 1 (dengue-1) neutralized the American genotype of dengue serotype 2 (American-2) to a greater ex- tent than it neutralized the Asian genotype of dengue serotype 2 (Asian-2). To determine if this activity is protective, Aotus nancymac monkeys were infected with dengue-1 followed by either American-2 or Asian-2. Dengue- 1-infected animals produced antibody with neutralizing titers of 2656 antibodies against dengue-1, 409 against American-2, and <20 against Asian-2. Infection with American-2 did not produce detectable viremia in either dengue-1-immune or den- gue-1-naive animals. These findings support the hypothesis that dengue- 1 immunity might have prevented disease or altered the severity of disease in individuals sequentially infected with dengue-1 and American-2. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNOGLOBULINS
BLOOD plasma
DENGUE
GENETIC research
SERUM
NEUTRALIZATION (Chemistry)
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 191
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 16261075
- Full Text :
- https://doi.org/10.1086/427511