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Desipramine treatment for cocaine dependence in buprenorphine- or methadone-treated patients: baseline urine results as predictor of response.
- Source :
- American Journal on Addictions; Jan/Feb2005, Vol. 14 Issue 1, p8-17, 10p, 2 Charts
- Publication Year :
- 2005
-
Abstract
- The prognostic importance of baseline urines for cocaine was examined in a randomized, placebo-controlled, twelve-week clinical trial in 165 opioid- and cocaine-dependent patients who were treated with desipramine (DMI) in combination with buprenorphine (BUP) or methadone (Meth). Patients with a cocaine-positive urine at baseline (CU+) had significantly fewer cocaine-free urines than those with a negative urine at baseline (CU-neg). The CU+ patients showed a treatment effect of DMI. This DMI effect was significant in patients maintained on BUP but not on Meth. [ABSTRACT FROM AUTHOR]
- Subjects :
- URINE
COCAINE
PLACEBOS
DRUG abuse
CLINICAL trials
BODY fluids
METHADONE treatment programs
BUPRENORPHINE
NARCOTIC antagonists
ADRENERGIC uptake inhibitors
DESIPRAMINE
COMPARATIVE studies
RESEARCH methodology
DOPAMINE uptake inhibitors
MEDICAL cooperation
PROGNOSIS
RESEARCH
RESEARCH funding
SUBSTANCE abuse
URINALYSIS
SUBSTANCE abuse treatment
EVALUATION research
RANDOMIZED controlled trials
TREATMENT effectiveness
PREDICTIVE tests
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 10550496
- Volume :
- 14
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- American Journal on Addictions
- Publication Type :
- Academic Journal
- Accession number :
- 16257001
- Full Text :
- https://doi.org/10.1080/10550490590899817