2,4,6‐Tris(dimethylaminomethyl)phenol: The allergen which came in from the cold.

Keywords: 2,4,6-Tris(dimethylaminomethyl)phenol; CAS 90-72-2; epoxy resin; patch testing; tris-DMP EN 2,4,6-Tris(dimethylaminomethyl)phenol CAS 90-72-2 epoxy resin patch testing tris-DMP 316 318 3 03/15/23 20230401 NES 230401 2,4,6-Tris(dimethylaminomethyl)phenol (tris-DMP; CAS No. 90-72-2) is a hardener/accelerator frequently used in epoxy resin systems (ERS), especially at low ambient temperature.[1] First cases of contact sensitization to tris-DMP have been observed at the Finnish Institute of Occupational Health (FIOH) around 1990.[2] Since then, contact sensitization to tris-DMP has been described in several case reports from various European countries.[1] In the FIOH, 14 cases of contact sensitization to tris-DMP have been registered from 1991 to 2013, rendering it the second most frequent sensitizer among epoxy resin hardeners.[1] Since 2016, tris-DMP is available as patch test preparation at 0.5% in pet. from Chemotechnique, Vellinge, Sweden. However, 9 out of 14 FIOH patients (64%) sensitized to tris-DMP, but only 3 of the 28 tris-DMP positive IVDK patients (11%), were painters. DISCUSSION Consistent with the FIOH data,[1] we found sensitizations to tris-DMP less frequently than sensitizations to MXDA, but with a similar frequency as sensitizations to IPDA. [Extracted from the article]