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Ginsenoside Rg5: A Review of Anticancer and Neuroprotection with Network Pharmacology Approach.
- Source :
- American Journal of Chinese Medicine; 2022, Vol. 50 Issue 8, p2033-2056, 24p
- Publication Year :
- 2022
-
Abstract
- Ginsenoside Rg5 (G-Rg5) is a rare ginsenoside isolated from ginseng (Panax ginseng C.A. Meyer), and this compound is increasingly known for its potent pharmacological activities. This study aimed to provide a comprehensive review of the main activities and mechanisms of G-Rg5 by adopting network pharmacological analysis combined with a summary of published articles. The 100 target genes of G-Rg5 were searched through available database, subjected to protein–protein interaction (PPI) network generation and then core screening. The results showed that G-Rg5 has promising anticancer and neuroprotective effects. By summarizing these two pharmacological activities, we found that G-Rg5 exerts its therapeutic effects mainly through PI3K/AKT, MAPK signaling pathways, and the regulation of apoptosis and cell cycle. And these results were corroborated by KEGG analysis. Likewise, molecular docking of the related proteins was performed, and the binding energies were all less than − 7.0 kJ/mol, indicating that these proteins had excellent binding capacity with G-Rg5. The network pharmacology results revealed many potential G-Rg5 mechanisms, which need to be further explored. We expect that the network pharmacology approach and molecular docking techniques can help us gain a deeper understanding of the therapeutic mechanisms of different ginsenosides and even the ginseng plant, for further developing their therapeutic potential as well as clinical applications. [ABSTRACT FROM AUTHOR]
- Subjects :
- PROTEIN kinases
ANTIDEPRESSANTS
TRITERPENES
ONCOGENES
PHOSPHOTRANSFERASES
ANTI-inflammatory agents
ANTINEOPLASTIC agents
APOPTOSIS
SIGNAL peptides
BIOINFORMATICS
CELLULAR signal transduction
CELL cycle
GENE expression
NEUROPROTECTIVE agents
GENES
CANCER genes
MENTAL depression
PHARMACEUTICAL chemistry
TUMORS
COMPUTER-assisted molecular modeling
MITOGEN-activated protein kinases
PLANT extracts
INSOMNIA
GINSENG
NEURODEGENERATION
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 0192415X
- Volume :
- 50
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- American Journal of Chinese Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 162295984
- Full Text :
- https://doi.org/10.1142/S0192415X22500872