Fracture incidence in children after developing atopic dermatitis: A Korean nationwide birth cohort study.

Previous studies have determined the relationship between atopic dermatitis (AD) and the risk of fractures.[[1], [3]] However, there may be inconclusive due to inappropriate study design, existing recall bias, inadequate adjustment for confounders, small sample size, short-term follow-up period, and inclusion of adult participants only.[[1], [3]] This large-scale, population-based, nationwide birth cohort study investigated the relationship between AD diagnosis and fracture incidence in 1.78 million children in South Korea. The excess risk for overall fracture following AD diagnosis was greater at 0-1 year of age after AD diagnosis (aHR, 1.53; 95% CI: 1.49-1.57), and this risk persisted until 5 years of age (Figure 1). [Extracted from the article]