Effective Connectivity Based EEG Revealing the Inhibitory Deficits for Distracting Stimuli in Major Depression Disorders.

Emotional conflict control is impaired in major depression disorders (MDDs) and affects decision-making with further consequent social interactions dysfunction. However, neural correlates of conflict monitoring processes being modulated by different affective distractor stimuli are not clear in MDDs. In this article, we investigated abnormal neural basis of conflict monitoring processes in MDD patients by applying dynamic causal modeling (DCM) technique on electroencephalography (EEG). The results indicated that MDD patients showed lower N2 amplitudes regardless of stimulus conditions, and reduced activation within ACC region for incongruent stimuli, relative to healthy controls. Especially, MDDs had more negative N2 amplitudes to happy incongruent trials than happy congruent trials. Source localization analyses revealed that MDD patients had significantly enhanced left inferior temporal gyrus (ITG) activation, which is involved in written words processing. Further DCM analysis provided abnormal neural correlates through greater backward connections (fusiform→ITG, amygdala→ITG) on happy incongruent trials than happy congruent trials in MDD group. These findings indicate that only sad words induce significantly greater interference effects to positive target faces in MDD patients, which may be associated with ITG activity dysfunction. The findings may share new insights into the neural mechanisms of emotional conflict processing in MDDs. [ABSTRACT FROM AUTHOR]