Molecular Research on Reproductive Toxicity.

In the second article of Soria-Tiedemann et al. [[2]], starting from the information that Arachidonate 15-lipoxygenase (Alox15) and Glutathione peroxidase 4 (Gpx4) enzymes are both involved in sperm maturation, the authors explored the potential roles of these enzymes in acrosomal exocytosis and in vitro fertilization. Taking advantage of previous data demonstrating the high toxicity of this herbicide on the liver of these animals [[11]], the authors evaluated testicular structure, steroidogenesis and estrogen receptor expression/localization after oral exposure to Gly. In the study by Ge et al. [[5]], the effect of a drop in temperature on zebrafish spawning was investigated and key genes, hub pathways and important biological processes closely associated with female spawning were identified through the transcriptomic analysis of zebrafish brain tissue. Fertility rates in animals have shown a progressive decrease in recent decades, and reproductive toxicity is considered an important regulatory endpoint in health hazard assessment. [Extracted from the article]