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N-Amidation of Nitrogen-Containing Heterocyclic Compounds: Can We Apply Enzymatic Tools?
- Source :
- Bioengineering (Basel); Feb2023, Vol. 10 Issue 2, p222, 15p
- Publication Year :
- 2023
-
Abstract
- Amide bond is often seen in value-added nitrogen-containing heterocyclic compounds, which can present promising chemical, biological, and pharmaceutical significance. However, current synthesis methods in the preparation of amide-containing N-heterocyclic compounds have low specificity (large amount of by-products) and efficiency. In this study, we focused on reviewing the feasible enzymes (nitrogen acetyltransferase, carboxylic acid reductase, lipase, and cutinase) for the amidation of N-heterocyclic compounds; summarizing their advantages and weakness in the specific applications; and further predicting candidate enzymes through in silico structure-functional analysis. For future prospects, current enzymes demand further engineering and improving for practical industrial applications and more enzymatic tools need to be explored and developed for a broader range of N-heterocyclic substrates. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 23065354
- Volume :
- 10
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Bioengineering (Basel)
- Publication Type :
- Academic Journal
- Accession number :
- 162086853
- Full Text :
- https://doi.org/10.3390/bioengineering10020222