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Integrative systems immunology uncovers molecular networks of the cell cycle that stratify COVID‐19 severity.

Authors :
Prado, Caroline Aliane de Souza
Fonseca, Dennyson Leandro M.
Singh, Youvika
Filgueiras, Igor Salerno
Baiocchi, Gabriela Crispim
Plaça, Desirée Rodrigues
Marques, Alexandre H. C.
Dantas‐Komatsu, Raquel Costa Silva
Usuda, Júlia N.
Freire, Paula Paccielli
Salgado, Ranieri Coelho
Napoleao, Sarah Maria da Silva
Ramos, Rodrigo Nalio
Rocha, Vanderson
Zhou, Guangyan
Catar, Rusan
Moll, Guido
Camara, Niels Olsen Saraiva
de Miranda, Gustavo Cabral
Calich, Vera Lúcia Garcia
Source :
Journal of Medical Virology; Feb2023, Vol. 95 Issue 2, p1-18, 18p
Publication Year :
2023

Abstract

Several perturbations in the number of peripheral blood leukocytes, such as neutrophilia and lymphopenia associated with Coronavirus disease 2019 (COVID‐19) severity, point to systemic molecular cell cycle alterations during severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection. However, the landscape of cell cycle alterations in COVID‐19 remains primarily unexplored. Here, we performed an integrative systems immunology analysis of publicly available proteome and transcriptome data to characterize global changes in the cell cycle signature of COVID‐19 patients. We found significantly enriched cell cycle‐associated gene co‐expression modules and an interconnected network of cell cycle‐associated differentially expressed proteins (DEPs) and genes (DEGs) by integrating the molecular data of 1469 individuals (981 SARS‐CoV‐2 infected patients and 488 controls [either healthy controls or individuals with other respiratory illnesses]). Among these DEPs and DEGs are several cyclins, cell division cycles, cyclin‐dependent kinases, and mini‐chromosome maintenance proteins. COVID‐19 patients partially shared the expression pattern of some cell cycle‐associated genes with other respiratory illnesses but exhibited some specific differential features. Notably, the cell cycle signature predominated in the patients' blood leukocytes (B, T, and natural killer cells) and was associated with COVID‐19 severity and disease trajectories. These results provide a unique global understanding of distinct alterations in cell cycle‐associated molecules in COVID‐19 patients, suggesting new putative pathways for therapeutic intervention. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01466615
Volume :
95
Issue :
2
Database :
Complementary Index
Journal :
Journal of Medical Virology
Publication Type :
Academic Journal
Accession number :
162082110
Full Text :
https://doi.org/10.1002/jmv.28450