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Diagnostic and prognostic significance of miR-451a in patients with atherosclerosis.
- Source :
- Vascular; Feb2023, Vol. 31 Issue 1, p47-53, 7p
- Publication Year :
- 2023
-
Abstract
- Objectives: Atherosclerosis (AS) is a chronic inflammatory vascular disease. This study aimed to detect the expression level of miR-451a and investigate the diagnostic and prognostic values of miR-451a for AS patients. Methods: The relative expression of miR-451a was assessed by qRT-PCR. Comparison of groups was analyzed with the t-test and chi-squared test. Pearson analysis was used to validate the correlation of miR-451 with CRP and CIMT. The receiver operating characteristic (ROC) curves, K-M analysis, and Cox regression analysis were conducted to explore the roles of miR-451a in diagnosing AS patients and predicting outcomes of AS patients. Results: The expression of miR-451a was significantly decreased in the serum of AS patients. The results of Pearson analysis showed the expression of miR-451a was negatively correlated with CRP and CIMT. The data of ROC proposed miR-451a could differentiate AS patients from healthy individuals with high sensitivity and specificity. K-M analysis and Cox regression showed miR-451a might be an independent biomarker of suffering cardiovascular endpoint diseases in AS patients. The expression of miR-451a was obviously inhibited in AS patients with cardiovascular endpoint events. Conclusion: Deregulation of miR-451a might be associated with the development of AS. MiR-451a might be used as a promising diagnostic and prognostic biomarker for clinical treatment of AS patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17085381
- Volume :
- 31
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Vascular
- Publication Type :
- Academic Journal
- Accession number :
- 161970544
- Full Text :
- https://doi.org/10.1177/17085381211058571