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The immune-chemo-embolization effect of temperature sensitive gold nanomedicines against liver cancer.
- Source :
- Nano Research; Feb2023, Vol. 16 Issue 2, p2749-2761, 13p
- Publication Year :
- 2023
-
Abstract
- Although transcatheter arterial chemo-embolization (TACE) plays a key role on clinical treatment of hepatocellular carcinoma (HCC), it was greatly limited by the poor synergistic effect between chemotherapeutics and physical embolization to tumor-feeding arteries. In the present work, a temperature sensitive polymer poly(N-isopropylacrylamide-b-methacrylic acid) (PNA), which was modified with gold nanoparticles (AuNP@PNA), was successfully used to encapsulate doxorubicin (DOX) by electrostatic binding with their carboxyl groups. The resultant gold nanomedicines (AuNP@PNA/DOX) exhibited temperature responsive sol-gel phase transition, favorable shear thinning effect and X-ray angiography. By in vivo evaluation of vascular embolization on VX2-tumor-bearing rabbits, AuNP@PNA/DOX exhibited far better antitumor efficacy than Lipiodol/DOX, on either tumor growth inhibition, proliferation, apoptosis, necrosis or anti-metastasis. Owing to sufficient embolization to tumor vascular networks, AuNP@PNA/DOX down-regulated the expression levels of HIF-1α, VEGF and MMP-9, and prompted more efficient activation on CD3<superscript>+</superscript>/CD8<superscript>+</superscript> T cells and the related cytokines, suggesting the synergistic effect between AuNP@PNA and DOX on the improvement of post-operative tumor immunosuppressive microenvironment. With their favorable pharmcokinetics and biocompatibility, AuNP@PNA/DOX is promising to be developed as a multi-functional artery-imaging/embolic agent with immune-chemo-embolization for enhancing TACE efficacy on HCC. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19980124
- Volume :
- 16
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Nano Research
- Publication Type :
- Academic Journal
- Accession number :
- 161959283
- Full Text :
- https://doi.org/10.1007/s12274-022-4921-2