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TheRole of Interleukin 6 inSubstance Use Disorder Treatment Failure.
- Source :
- Journal of Addictions Nursing; Oct-Dec2022, Vol. 33 Issue 4, pE5-E25, 21p, 3 Diagrams, 3 Charts
- Publication Year :
- 2022
-
Abstract
- Substance use disorders (SUDs) are often misunderstood as a reflection of an individual's lack of motivation or willpower or as a moral failing. SUDs are complex and require a biopsychosocial lens to understand the phenomenon, particularly treatment failure, which is described as a deficit in patients' willpower/self-regulation or dedication to managing their condition. Recent evidence has implicated inflammatory cytokines such as interleukin 6 (IL-6) in the action of substance use by impairing executive functioning, which is an essential aspect of self-regulatory control. Emerging research indicates that inflammation may also shape social behavior, including social withdrawal and approach, thus having potential implications on health-seeking and health-sustaining behaviors often interpreted as a dedication to managing health conditions. The aim of this two-part biobehavioral synthesis is to (a) examine the scientific evidence of the role of IL-6 in self-regulatory failure, (b) explore IL-6 as a common inflammatory mechanism across SUDs, and (c) investigate the role of IL-6 in social withdrawal and approach to gain an understanding of how this determinant may impact treatment failure. Overall, the evidence supports a new paradigm of treatment failure that stresses the influence of IL-6 on self-regulatory failure by way of dual cognitive processing and the role of IL-6 in shaping social behavior central to health-seeking and health-sustaining behaviors. This discovery will help to minimize stigma and blame. Understanding the role of IL-6 in treatment failure may elucidate novel targets for intervention, improve treatment outcomes, and break the social disconnection cycle often seen in SUDs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10884602
- Volume :
- 33
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Journal of Addictions Nursing
- Publication Type :
- Academic Journal
- Accession number :
- 161944197
- Full Text :
- https://doi.org/10.1097/JAN.0000000000000490