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Leveraging CTSA hubs for rapid, large-scale, high-impact research: A case study during a global public health emergency.

Authors :
Croker, Jennifer A.
Valenti, Shannon
Baus, Holly Ann
Ford, Eric W.
Mathias, David
Yasko, Laurel
McGaughey, Dan
Smith, Tony
Underwood, Katherine
Avolio, Jennifer
Sadtler, Kaitlyn
Memoli, Matthew J.
Kimberly, Robert P.
Reis, Steven E.
Source :
Journal of Clinical & Translational Science; 2023, Vol. 7 Issue 1, p1-6, 6p
Publication Year :
2023

Abstract

As the COVID-19 pandemic took hold in the USA in early 2020, it became clear that knowledge of the prevalence of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among asymptomatic individuals could inform public health policy decisions and provide insight into the impact of the infection on vulnerable populations. Two Clinical and Translational Science Award (CTSA) Hubs and the National Institutes of Health (NIH) set forth to conduct a national seroprevalence survey to assess the infection's rate of spread. This partnership was able to quickly design and launch the project by leveraging established research capacities, prior experiences in large-scale, multisite studies and a highly skilled workforce of CTSA hubs and unique experimental capabilities at the NIH to conduct a diverse prospective, longitudinal observational cohort of 11,382 participants who provided biospecimens and participant-reported health and behavior data. The study was completed in 16 months and benefitted from transdisciplinary teamwork, information technology innovations, multimodal communication strategies, and scientific partnership for rigor in design and analytic methods. The lessons learned by the rapid implementation and dissemination of this national study is valuable in guiding future multisite projects as well as preparation for other public health emergencies and pandemics. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20598661
Volume :
7
Issue :
1
Database :
Complementary Index
Journal :
Journal of Clinical & Translational Science
Publication Type :
Academic Journal
Accession number :
161901056
Full Text :
https://doi.org/10.1017/cts.2022.484