Synthesis and characterizations of a new Sulfamethoxazole-molecularly imprinted polymer and using for pharmaceutical application.

The molecularly imprinted polymer prepared by using Sulfamethoxazole (SMT) as the template as well as allyl chloride (AYC) as monomer, used (TMPTA) trimethylolpropane tri acrylate as cross-linker and initiator using (BP) benzyl peroxide. By used different plasticizers (di butyl Phthalate (DBPH), Nitrobenzene (NB), oleic acid (OA) and paraffin) membranes of MIPs were prepared in PVC matrix. The characterizations of each electrode were determined The Slope range from (55.946 - 43.271) mV/decade, Limit of Detection (1x10 ⁻¹ – 1x 10 ⁻⁵) and Linearity range of electrodes MIPs from (1 X 10 ⁻⁶ - 6 X 10 ⁻⁷). Stable Signe of electrode pH from (3.5-9.5) and study the selectivity with additives of drugs synthesis (Glucose, Calcium stearate, sodium benzoate and benzoic acid) demonstrate strong selectivity. [ABSTRACT FROM AUTHOR]