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Opisthorchis Felineus Infection is a Risk Factor for Cholangiocarcinoma in Western Siberia: A Hospital-based Case-control Study.
- Source :
- Clinical Infectious Diseases; 2/1/2023, Vol. 76 Issue 3, pe1392-e1398, 7p
- Publication Year :
- 2023
-
Abstract
- Background Cholangiocarcinoma (CCA), a fatal bile duct cancer, has a high incidence in Western Siberia, Russian Federation. In addition, Opisthorchis felineus , a bile duct–dwelling trematode liver fluke is highly endemic. Closely related species have been shown to be cancerogenic agents in Asia. We therefore examined the association between O felineus infection and CCA in Western Siberia. Methods We conducted a hospital-based, individually matched case-control study between January 2017 and August 2020 in Tomsk Oblast and Khanty-Mansiysk Autonomous Okrug, Yugra, Russian Federation. Histologically confirmed CCA patients (cases) were compared with matched age, sex, and place of residence hospital controls. The examination of study participants included the diagnosis of current and past O felineus infection, abdominal ultrasonographical assessment, physical examination, and interview on exposures to potential risk factors. Results We identified 40 patients with CCA and 160 controls. Exposures to O felineus infection was strongly associated with CCA (odds ratio [OR], 3.9; 95% confidence interval [CI], 1.4–10.8; P =.008). Also, cases reported more often that they were currently or in the past were infected by O felineus compared with controls (OR, 4.03; 95% CI, 1.7–9.5; P =.001). Furthermore, cases reported river fish consumption and fishing habits significantly more often than controls (OR, 5.5; 95% CI, 1.5–19.8; P =.009 and OR, 3.3; 95% CI, 1.4–7.7; P =.005). Conclusions The study results revealed a strong significantly increased risk for CCA development in O felineus –infected individuals. Elaboration of the guidelines on screening programs for early CCA diagnosis, prevention, and treatment is socially important in endemic regions. [ABSTRACT FROM AUTHOR]
- Subjects :
- ULTRASONIC imaging of the abdomen
HOSPITALS
PHYSICAL diagnosis
LIVER function tests
CONFIDENCE intervals
IMMUNOGLOBULINS
CHOLANGIOCARCINOMA
LIVER
MICROSCOPY
SERUM
FOOD consumption
CASE-control method
INTERVIEWING
ACQUISITION of data
EARLY detection of cancer
RISK assessment
FECES
FISHING
HOSPITAL care
RESEARCH funding
DESCRIPTIVE statistics
QUESTIONNAIRES
ENZYME-linked immunosorbent assay
MEDICAL records
BLOOD sedimentation
FISHES
SOCIAL classes
BILE ducts
ODDS ratio
DATA analysis software
ABDOMINAL pain
BLOOD cell count
SMOKING
STATISTICAL models
OPISTHORCHIASIS
DIETARY sodium
EARLY medical intervention
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 10584838
- Volume :
- 76
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Clinical Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 161829704
- Full Text :
- https://doi.org/10.1093/cid/ciac497