Reply to Letter about whole genome sequencing in newborns.

The key questions, as highlighted by Wojcik et al., are ones about the timing and sequencing of tests, the predictive value of tests, and the cost-benefit ratios of different approaches. Dear Editor, We are grateful to Wojcik and colleagues for their thoughtful critique of our paper. Dr Wojcik's claims that clinical diagnoses are often in error are supported by references to reports of diagnostic inaccuracy from autopsy series of adults. [Extracted from the article]