Attenuated live vaccine in children with solid organ transplantation on everolimus therapy: Report of two cases.

Keywords: children; everolimus; solid organ transplantation EN children everolimus solid organ transplantation 1 3 3 02/13/23 20230301 NES 230301 Abbreviations IgG immunoglobulin G MMR measles-mumps-rubella SOT solid organ transplantation INTRODUCTION In childhood, some vaccines may not be administered before solid organ transplantation (SOT) due to the age at the time of planned surgery, clinical status, and the lack of sufficient time between transplantation and vaccination.[1] Although there was indecisiveness about the attenuated live vaccine administration to children after SOT, current studies and consensus recommendations reported that it can be administered in selected cases.[[2]] Here, attenuated live vaccine administration is described in two cases who had to use everolimus instead of tacrolimus after SOT. It was noticed that the varicella vaccine had not been administered, and she tested negative for varicella IgG. [Extracted from the article]