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Synthesis and Antioxidant and Antibacterial Activities of Novel 4-({[3-Alkyl(aryl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-4-yl]imino}-methyl)phenyl 4-Nitrobenzoate Derivatives.
- Source :
- Russian Journal of Organic Chemistry; Dec2022, Vol. 58 Issue 12, p1839-1850, 12p
- Publication Year :
- 2022
-
Abstract
- It is known that acetyl derivatives, Schiff bases, and Mannich bases obtained from 1,2,4-triazol-5-ones have significant antibacterial and antioxidant activities. Herein, 27 new 1,2,4-triazole derivatives were synthesized, and their antioxidant and antibacterial properties were investigated. The metal chelating activity of the synthesized compounds and especially the effect against gram-positive bacteria were found to be significant. The effect against gram-negative strains was also important. Structure determination of the synthesized com-pounds was performed on the basis of their <superscript>1</superscript>H and <superscript>13</superscript>C NMR, IR, and high-resolution mass spectra. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10704280
- Volume :
- 58
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Russian Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 161769129
- Full Text :
- https://doi.org/10.1134/S1070428022120132