Dietary Brewer Grain Meal with Multienzymes Supplementation Affects Growth Performance, Gut Health, and Antioxidative Status of Weaning Pigs.

We conducted a 28-day feeding study on 80 weaning pigs [(Landrace × Large White) × Duroc] to determine the effects of dietary inclusion with brewer's grain meal (BGM) and multienzymes on their growth, intestinal health, and antioxidative status. Piglets were grouped by sex and initial BW and assigned to 20 pens with four pigs each. Treatments were a corn–soybean meal-based diet with either 0.1% multienzyme addition (PC) or without (NC), and two BGM compositions fortified with 0.1% multienzyme: 10% (BGM10) and 20% (BGM20). The overall body weight, average daily weight gain, and weight gain:feed ratio were significantly greater in pigs fed BGM20 than those fed the NC diet (p < 0.05). Moreover, the BGM diets significantly increased the digestibility of total ash and ether extract, glucose, total protein, immunoglobulin A, total antioxidant capacity, superoxide dismutase, heart and small intestine weights, villus height: crypt depth ratio (VH/CD), and Lactobacillus spp. count compared with the NC diet (p < 0.05). The diarrheal rate, blood urea nitrogen, malondialdehyde, duodenal crypt depth, and Salmonella spp. count were reduced in pigs fed the BGM-supplemented diet than those fed the NC diet (p < 0.05). The diarrheal rate (p = 0.010), ether extract digestibility (p = 0.044), total protein (p = 0.044), and duodenal villus height and VH/CD (p = 0.003 and p = 0.002, respectively) decreased quadratically with the increase in BGM supplementation. Overall, diets containing up to 20% BGM with multienzyme addition improved the nutrient utilization and intestinal health in weaning pigs by suppressing pathogenic bacterial growth without compromising the overall growth of the pigs. [ABSTRACT FROM AUTHOR]