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Collective Synthesis of Chiral Tetrasubstituted Cyclobutanes Enabled by Enantioconvergent Negishi Cross‐Coupling of Cyclobutenones.

Authors :
Yan, Min
Zhou, Qiang
Lu, Ping
Source :
Angewandte Chemie; 2/6/2023, Vol. 135 Issue 7, p1-5, 5p
Publication Year :
2023

Abstract

Cyclobutenones provide a straightforward four‐carbon ring platform for further structural elaborations in that every carbon atom of the ring could be potentially functionalized. We report here a nickel catalyzed enantioconvergent Negishi coupling of 4‐iodocyclobutenones with an array of aryl or alkenyl zinc reagents to access enantioenriched 4‐substituted cyclobutenones, from which a modular approach to the synthesis of 1,2,3,4‐tetrasubstituted cyclobutanes was demonstrated. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00448249
Volume :
135
Issue :
7
Database :
Complementary Index
Journal :
Angewandte Chemie
Publication Type :
Academic Journal
Accession number :
161691356
Full Text :
https://doi.org/10.1002/ange.202218008