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The common variant of rs6214 in insulin like growth factor 1 (IGF1) gene: a potential protective factor for non-alcoholic fatty liver disease.

Authors :
Sabzikarian, Mohammad
Mahmoudi, Touraj
Tabaeian, Seidamir Pasha
Rezamand, Gholamreza
Asadi, Asadollah
Farahani, Hamid
Nobakht, Hossein
Dabiri, Reza
Mansour-Ghanaei, Fariborz
Derakhshan, Faramarz
Zali, Mohammad Reza
Source :
Archives of Physiology & Biochemistry; Feb2023, Vol. 129 Issue 1, p10-15, 6p
Publication Year :
2023

Abstract

Regarding the central role of insulin resistance in NAFLD, we explored whether insulin-like growth factor 1 (IGF1) and insulin-like growth factor-binding protein 3 (IGFBP3) gene variants were associated with NAFLD susceptibility. IGF1 (rs6214) and IGFBP3 (rs3110697) gene variants were genotyped in 154 cases with biopsy-proven NAFLD and 156 controls using PCR-RFLP method. The IGF1 rs6214 "AA + AG" genotype compared with the "GG" genotype appeared to be a marker of decreased NAFLD susceptibility (p =.006; OR = 0.47, 95%CI = 0.28–0.80). Furthermore, the IGF1 rs6214 "A" allele was underrepresented in the cases than controls (p =.024; OR = 0.61, 95%CI = 0.40–0.94). However, we observed no significant difference in genotype or allele frequencies between the cases and controls for IGFBP3 gene. To our knowledge, these findings suggest, for the first time, that the IGF1 rs6214 "A" allele and "AA + AG" genotype have protective effects for NAFLD susceptibility. Nonetheless, further studies are needed to validate our findings. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13813455
Volume :
129
Issue :
1
Database :
Complementary Index
Journal :
Archives of Physiology & Biochemistry
Publication Type :
Academic Journal
Accession number :
161688088
Full Text :
https://doi.org/10.1080/13813455.2020.1791187