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Toll‐like receptors control the accumulation of neutrophils in lymph nodes that expand CD4+ T cells during experimental autoimmune encephalomyelitis.
- Source :
- European Journal of Immunology; Feb2023, Vol. 53 Issue 2, p1-10, 10p
- Publication Year :
- 2023
-
Abstract
- Toll‐like receptors (TLR) control the activation of dendritic cells that prime CD4+ T cells in draining lymph nodes, where these T cells then undergo massive clonal expansion. The mechanisms controlling this clonal T cell expansion are poorly defined. Using the CD4+ T cell‐mediated disease experimental autoimmune encephalomyelitis (EAE), we show here that this process is markedly suppressed when TLR9 signaling is increased, without noticeably affecting the transcriptome of primed T cells, indicating a purely quantitative effect on CD4+ T cell expansion. Addressing the underpinning mechanisms revealed that CD4+ T cell expansion was preceded and depended on the accumulation of neutrophils in lymph nodes a few days after immunization. Underlying the importance of this immune regulation pathway, blocking neutrophil accumulation in lymph nodes by treating mice with a TLR9 agonist inhibited EAE progression in mice with defects in regulatory T cells or regulatory B cells, which otherwise developed a severe chronic disease. Collectively, this study demonstrates the key role of neutrophils in the quantitative regulation of antigen‐specific CD4+ T cell expansion in lymph nodes, and the counter‐regulatory role of TLR signaling in this process. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
REGULATORY T cells
TOLL-like receptors
REGULATORY B cells
LYMPH nodes
Subjects
Details
- Language :
- English
- ISSN :
- 00142980
- Volume :
- 53
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- European Journal of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 161658214
- Full Text :
- https://doi.org/10.1002/eji.202250059