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Management of Hepatitis C in Children — A New Paradigm.
- Source :
- Indian Pediatrics; Jan2023, Vol. 60 Issue 1, p55-62, 8p
- Publication Year :
- 2023
-
Abstract
- Introduction: With the advent of direct-acting antivirals (DAAs), the past decade has seen a paradigm shift in the management of hepatitis C (HCV) infection in children. In this review, we summarize the various treatment options for pediatric HCV infection, highlighting the recent changes in the management. Methods: A literature search was performed using the PubMed database with the relevant keywords. Filters included were human, ages 0–18 years, and the English language. Results: Initial phase of HCV treatment using conventional or pegylated interferon and ribavirin combination regimens yielded poor outcomes in children, especially in genotypes 1 and 4, with an overall sustained virologic response of 58%. Also, treatment with interferon and ribavirin combination was associated with significant side effects in up to 52% of those treated. Presently, various combinations of direct-acting antivirals (DAAs) have been approved in children above three years of age with documented evidence of high efficacy (SVR12 of 92% to 100%) and excellent safety, and the current standard of care. Conclusion: With various DAA regimens now being approved for children above three years of age, the treatment of active HCV infection (HCV-RNA positive) in children has become simple. Besides the effectiveness of DAA therapy, public awareness about HCV transmission, better screening, and making the DAAs available at a subsidized price in the public sectors are necessary to eliminate HCV infection in India. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTIVIRAL agents
RIBAVIRIN
INTERFERONS
HEPATITIS C
DATABASES
PEDIATRIC therapy
Subjects
Details
- Language :
- English
- ISSN :
- 00196061
- Volume :
- 60
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Indian Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 161606894
- Full Text :
- https://doi.org/10.1007/s13312-023-2696-5