Back to Search
Start Over
Association of metformin use with fracture risk in type 2 diabetes: A systematic review and meta-analysis of observational studies.
- Source :
- Frontiers in Endocrinology; 1/11/2023, Vol. 13, p1-11, 11p
- Publication Year :
- 2023
-
Abstract
- Aims: Increasing evidence suggests that metformin can affect bone metabolism beyond its hypoglycemic effects in diabetic patients. However, the effects of metformin on fracture risk in type 2 diabetes mellitus (T2DM) patients remain unclear. A systematic review and meta-analysis were performed in this study to evaluate the association between metformin application and fracture risk in T2DM patients based on previous studies published until June 2021. Methods: A systematic search was performed to collect publications on metformin application in T2DM patients based on PubMed, Embase, Cochran, and Web of Science databases. Meta-analysis was performed by using a random-effects model to estimate the summary relative risks (RRs) with 95% confidence intervals (CIs). Subgroup analyses based on cohort/casecontrol and ethnicity and sensitivity analyses were also performed. Results: Eleven studies were included in the meta-analysis. Results demonstrated metformin use was not significantly associated with a decreased risk of fracture (RR, 0.91; 95% CI, 0.81-1.02; I² = 96.8%). Moreover, metformin use also demonstrated similar results in subgroup analyses of seven cohort studies and four case-control studies, respectively (RR, 0.90; 95% CI, 0.76-1.07; I² = 98.0%; RR, 0.96; 96% CI, 0.89-1.03; I² = 53.7%). Sensitivity analysis revealed that there was no publication bias. Conclusion: There was no significant correlation between fracture risk and metformin application in T2DM patients. Due to a limited number of existing studies, further research is needed to make a definite conclusion for clinical consensus. [ABSTRACT FROM AUTHOR]
- Subjects :
- TYPE 2 diabetes
METFORMIN
SCIENTIFIC observation
SCIENCE databases
WEB databases
Subjects
Details
- Language :
- English
- ISSN :
- 16642392
- Volume :
- 13
- Database :
- Complementary Index
- Journal :
- Frontiers in Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 161596657
- Full Text :
- https://doi.org/10.3389/fendo.2022.1038603