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Effect of Salts on the Conformational Dynamics of the Cytochrome P450 OleP.
- Source :
- Molecules; Jan2023, Vol. 28 Issue 2, p832, 15p
- Publication Year :
- 2023
-
Abstract
- Cytochrome P450 OleP catalytic activity is strongly influenced by its structural dynamic conformational behavior. Here, we combine equilibrium-binding experiments with all-atom molecular dynamics simulations to clarify how different environments affect OleP conformational equilibrium between the open and the closed—catalytic competent—forms. Our data clearly show that at high-ionic strength conditions, the closed form is favored, and, very interestingly, different mechanisms, depending on the chemistry of the cations, can be used to rationalize such an effect. [ABSTRACT FROM AUTHOR]
- Subjects :
- CYTOCHROME P-450
MOLECULAR dynamics
CYTOCHROME c
CATALYTIC activity
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 28
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 161565277
- Full Text :
- https://doi.org/10.3390/molecules28020832