Prodromes predict attacks of hereditary angioedema: Results of a prospective study.

Keywords: attacks; hereditary angioedema; patient-reported outcomes; prodromes EN attacks hereditary angioedema patient-reported outcomes prodromes 577 579 3 01/31/23 20230201 NES 230201 Hereditary angioedema (HAE) is a lifetime disease characterized by repetitive bouts of tissue edema.[1] Early signs, symptoms, and perceptions (prodromes) are manifested by subjective and objective signals, preceding attacks by several hours.[[2]] Using a new HAE-specific instrument, we have recently shown that patients can identify prodromes and are able to predict oncoming attacks.[4] However, that study was retrospective, which might have been affected by recall bias. Mean duration of prodromes was significantly shorter than attacks, and prodromes overlapped the attack in 24.3% of cases. The study highlights the predictive value of prodromes as forecasters of attacks.[[2], [4]] It affirms that patients can clearly distinguish prodromes from attacks. [Extracted from the article]