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Panax notoginseng Alleviates Colitis via the Regulation of Gut Microbiota.

Authors :
Wang, Li
Shao, Li
Chen, Man-Yun
Wang, Lin
Yang, Pu
Tan, Feng-Bo
Zhang, Wei
Huang, Wei-Hua
Source :
American Journal of Chinese Medicine; 2023, Vol. 51 Issue 1, p107-127, 21p
Publication Year :
2023

Abstract

Gut microbiota are significantly associated with the occurrence and development of inflammatory bowel disease (IBD). Panax notoginseng saponins (PNS) could be used for colitis and to modulate gut microbiota. However, the mechanism behind the effects of PNS on anti-colitis that are pertinent to gut microbiota is largely unknown. This study aimed to evaluate the anti-colitis effects of PNS and explore the involved mechanism as it is related to gut microbiota. Results showed that PNS significantly alleviated dextran sulfate sodium (DSS)-induced colitis. Meanwhile, after PNS treatment, the tight junction proteins were enhanced and proinflammatory cytokines, such as TNF- α , IL-6, IL-1 β , and IL-17, were decreased. Furthermore, Bacteroides spp. were significantly increased after modeling, while PNS reduced their abundance and significantly increased the amount of Akkermansia spp. in vivo. Importantly, Akkermansia spp. and Bacteroides spp. were correlated with the IBD disease indicators. Moreover, fecal microbiota transplantation (FMT) experiments confirmed that PNS-reshaped gut microbiota significantly alleviated DSS-induced colitis, while A. muciniphila significantly reduced the levels of the LPS-induced cellular inflammatory factors IL-1 β and TNF- α. In conclusion, PNS alleviated colitis pertinent to the upregulation of Akkermania spp. and downregulation of Bacteroides spp. in the gut. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0192415X
Volume :
51
Issue :
1
Database :
Complementary Index
Journal :
American Journal of Chinese Medicine
Publication Type :
Academic Journal
Accession number :
161546768
Full Text :
https://doi.org/10.1142/S0192415X23500076