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New Chlorinated Metabolites and Antiproliferative Polyketone from the Mangrove Sediments-Derived Fungus Mollisia sp. SCSIO41409.
- Source :
- Marine Drugs; Jan2023, Vol. 21 Issue 1, p32, 11p
- Publication Year :
- 2023
-
Abstract
- Two new chlorinated metabolites, 8-chlorine-5-hydroxy-2,3-dimethyl-7-methoxychromone (1) and 3,4-dichloro-1H-pyrrole-2,5-dione (3), and eight known compounds (2 and 4–9) were isolated from the mangrove sediments-derived fungus Mollisia sp. SCSIO41409. Their structures were elucidated by physicochemical properties and extensive spectroscopic analysis. The absolute configuration of stemphone C (4) was established for the first time by the X-ray crystallographic analysis. Compounds 3 and 4 showed different intensity of antimicrobial activities against several pathogenic fungi and bacteria, and antiproliferative activities against two human prostate cancer cell lines (IC<subscript>50</subscript> values 2.77 to 9.60 μM). Further, stemphone C (4) showed a reducing PC-3 cell colony formation, inducing apoptosis and blocking the cell cycle at S-phase in a dose-dependent manner; thus, it could be considered as a potential antiproliferative agent and a promising anti-prostate cancer lead compound. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16603397
- Volume :
- 21
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Marine Drugs
- Publication Type :
- Academic Journal
- Accession number :
- 161476785
- Full Text :
- https://doi.org/10.3390/md21010032