Synthesis of 1‐Aminoisoquinolines and Their Application in a Host‐Guest Doped Strategy To Construct Ultralong Room‐Temperature Phosphorescence Materials for Bioimaging.

Organic ultralong room‐temperature phosphorescence (RTP) materials have attracted great attention for their wide applications in optoelectronic devices and bioimaging. However, the development of these materials remains a challenging task, partially due to the lack of rational molecular design strategies and unclear luminescence mechanisms. Herein, we present a method for facile access to structurally diverse substituted 1‐aminoisoquinoline derivatives through a copper‐catalyzed one‐pot three‐component coupling reaction that provides a promising approach to rapidly assemble a library of 1‐aminoisoquinolines for exploring the regularity of the host‐guest doped system. A series of host‐guest RTP materials with wide‐ranging lifetimes from 4.4 to 299.3 ms were constructed by doping various substituted isoquinolines derivatives into benzophenone (BP). Furthermore, 4 r/BP nanoparticles could be used for in‐vivo imaging with a signal‐to‐noise ratio value as high as 32, revealing the potential of the isoquinoline framework for the construction of high‐performance RTP materials. [ABSTRACT FROM AUTHOR]