Titration of flumazenil during awake craniotomy.

Keywords: Flumazenil; Remimazolam; Awake craniotomy; Titration EN Flumazenil Remimazolam Awake craniotomy Titration 166 167 2 01/25/23 20230201 NES 230201 This reply refers to the comment available online at https://doi.org/10.1007/s00540-022-03117-9. Therefore, the dose of 0.05 mg flumazenil for our patient might be sufficiently high as an initial dose to titrate the adequate dose, because it could be considered as nearly half that of the commonly accepted standard dose. Considering the generally accepted initial dose of 0.2 mg flumazenil to antagonize the sedative effect of benzodiazepine and the patient body size, we decided to administer 0.05 mg flumazenil as an initial dose for titration. [Extracted from the article]