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Thermo-Visco-Elastometry of RF-Wave-Heated and Ablated Flesh Tissues Containing Au Nanoparticles.

Thermo-Visco-Elastometry of RF-Wave-Heated and Ablated Flesh Tissues Containing Au Nanoparticles.

Authors :
Kurbanova, Bayan
Ashikbayeva, Zhannat
Amantayeva, Aida
Sametova, Akbota
Blanc, Wilfried
Gaipov, Abduzhappar
Tosi, Daniele
Utegulov, Zhandos
Source :
Biosensors (2079-6374); Jan2023, Vol. 13 Issue 1, p8, 11p
Publication Year :
2023

Abstract

We report non-contact laser-based Brillouin light-scattering (BLS) spectroscopy measurements of the viscoelastic properties of hyperthermally radiofrequency (RF)-heated and ablated bovine liver and chicken flesh tissues with embedded gold nanoparticles (AuNPs). The spatial lateral profile of the local surface temperature in the flesh samples during their hyperthermia was measured through optical backscattering reflectometry (OBR) using Mg–silica-NP-doped sensing fibers distributed with an RF applicator and correlated with viscoelastic variations in heat-affected and ablated tissues. Substantial changes in the tissue stiffness after heating and ablation were directly related to their heat-induced structural modifications. The main proteins responsible for muscle elasticity were denatured and irreversibly aggregated during the RF ablation. At T > 100 °C, the proteins constituting the flesh further shrank and became disorganized, leading to substantial plastic deformation of biotissues. Their uniform destruction with larger thermal lesions and a more viscoelastic network was attained via AuNP-mediated RF hyperthermal ablation. The results demonstrated here pave the way for simultaneous real-time hybrid optical sensing of viscoelasticity and local temperature in biotissues during their denaturation and gelation during hyperthermia for future applications that involve mechanical- and thermal-property-controlled theranostics. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20796374
Volume :
13
Issue :
1
Database :
Complementary Index
Journal :
Biosensors (2079-6374)
Publication Type :
Academic Journal
Accession number :
161436432
Full Text :
https://doi.org/10.3390/bios13010008