Back to Search
Start Over
Association of Dental Caries with Muscle Mass, Muscle Strength, and Sarcopenia: A Community-Based Study.
- Source :
- Journal of Nutrition, Health & Aging; Jan2023, Vol. 27 Issue 1, p10-20, 11p
- Publication Year :
- 2023
-
Abstract
- Objectives: Changes in the oral cavity can reflect other changes throughout the body. This study aimed to investigate the association of dental caries with muscle mass, muscle strength, and sarcopenia, and also to describe the microbial diversity, composition, and community structure of severe dental caries and sarcopenia. Design: Cross-sectional study based on a Chinese population aged from 50 to 85 years. Setting: Communities from Lanxi City, Zhejiang Province, China. Participants: A total of 1,442 participants aged from 50 to 85 years from a general community (62.8% women; median age 61.0 [interquartile range: 55.0, 68.0]). Measurements: Dental caries was assessed by the decayed, missing, and filled teeth (DMFT) index. Sarcopenia was defined as the presence of both low muscle mass (assessed by dual-energy X-ray absorptiometry scanning) and low muscle strength (assessed by handgrip strength). Multivariate logistic regression models were used to analyze the association of dental caries with muscle mass, muscle strength, and sarcopenia. Fecal samples underwent 16S rRNA profiling to evaluate the diversity and composition of the gut microbiota in patients with severe dental caries and/or sarcopenia. Results: In the fully adjusted logistic models, dental caries was positively associated with low muscle strength (DMFT ≥ 7: OR, 1.61; 95% CI, 1.25–2.06), and sarcopenia (DMFT ≥ 7: OR, 1.51; 95% CI, 1.01–2.26), but not low muscle mass. Severe dental caries was positively associated with higher alpha-diversity indices (richness, chao1, and ACE, all p < 0.05) and associated with beta-diversity based on Bray-Curtis distance (p = 0.006). The severe dental caries group and the sarcopenia group overlapped with 11 depleted and 13 enriched genera. Conclusion: Dental caries was positively associated with low muscle strength and sarcopenia but not muscle mass, and this association was more pronounced in male individuals. Significant differences were observed in gut microbiota composition both in severe dental caries and sarcopenia, and there was an overlap of the genera features. Future longitudinal studies are needed to clarify causal relationships. [ABSTRACT FROM AUTHOR]
- Subjects :
- RNA analysis
FECAL analysis
GRIP strength
PHOTON absorptiometry
CONFIDENCE intervals
GUT microbiome
CROSS-sectional method
MULTIPLE regression analysis
SARCOPENIA
RISK assessment
MUSCLE strength
GENE expression profiling
RESEARCH funding
DESCRIPTIVE statistics
DENTAL caries
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 12797707
- Volume :
- 27
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Nutrition, Health & Aging
- Publication Type :
- Academic Journal
- Accession number :
- 161347762
- Full Text :
- https://doi.org/10.1007/s12603-022-1875-8