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Echocardiographic features of left ventricular dysfunction and outcomes in chronic kidney disease.
- Source :
- Heart; Jan2023, Vol. 109 Issue 2, p134-142, 28p
- Publication Year :
- 2023
-
Abstract
- <bold>Objective: </bold>Heart failure (HF) imposes a substantial burden and the prevalence of HF is high in patients with chronic kidney disease (CKD). HF results in multiple hospital admissions, but whether HF subtypes worsen long-term outcomes and renal function in patients with CKD remains inconclusive.<bold>Methods: </bold>The study comprised 10 904 patients with CKD aged ≥20 years who underwent echocardiography between 1 January 2011 and 31 December 2018. The patients were stratified into four groups: non-HF, HF with reduced ejection fraction (HFrEF), HF with mildly reduced ejection fraction (HFmrEF) and HF with preserved ejection fraction (HFpEF). The primary end points were all-cause mortality, major adverse cardiovascular events (MACEs) and adverse renal outcomes.<bold>Results: </bold>In inverse probability of treatment weighting-adjusted method, the risk of all-cause mortality and MACEs relative to the non-HF group was greatest in the HFrEF group (HR 3.18 (95% CI 2.57 to 3.93) and HR 3.83 (95% CI 3.20 to 4.59)), followed by the HFmrEF (HR 2.75 (95% CI 2.22 to 3.42) and HR 3.08 (95% CI 2.57 to 3.69)) and HFpEF (HR 1.85 (95% CI 1.59 to 2.15) and HR 2.43 (95% CI 2.16 to 2.73) groups. In addition, the HFrEF group had the greatest risks of end-stage renal disease (HR 2.58 (95% CI 1.94 to 3.44)) compared with other groups.<bold>Conclusions: </bold>HF is associated with subsequent worse clinical outcomes, which may be more pronounced in patients with HFrEF, followed by those with HFmrEF and those with HFpEF relative to non-HF group. [ABSTRACT FROM AUTHOR]
- Subjects :
- HEART failure
CHRONIC kidney failure
LEFT ventricular dysfunction
Subjects
Details
- Language :
- English
- ISSN :
- 13556037
- Volume :
- 109
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Heart
- Publication Type :
- Academic Journal
- Accession number :
- 161273955
- Full Text :
- https://doi.org/10.1136/heartjnl-2022-321404