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Device-based neuromodulation for cardiovascular diseases and patient's age.

Device-based neuromodulation for cardiovascular diseases and patient's age.

Authors :
Mikhaylov, Evgeny N.
Gasimova, Nigar Z.
Belyaeva, Natalia N.
Leandro, Heber Ivan Condori
Vakhrushev, Aleksandr D.
Shlyakhto, Evgeny V.
Source :
Journal of Geriatric Cardiology; 2022, Vol. 19 Issue 11, p876-893, 18p
Publication Year :
2022

Abstract

The autonomic nervous system plays an important role in the pathogenesis of cardiovascular diseases. With aging, autonomic activity changes, and this impacts the physiological reactions to internal and external signals. Both sympathetic and parasympathetic responses seem to decline, reflecting functional and structural changes in nervous regulation. Although some investigators suggested that both the sympathetic and parasympathetic activities were suppressed, others found that only the parasympathetic activity was suppressed while the sympathetic activity increased. In addition, cardiac innervation progressively diminishes with aging. Therefore, one may suggest that neuromodulation interventions may have different effects, and older age groups can express an attenuated response. This article aims to discuss the effect of device-based neuromodulation in different cardiovascular diseases, depending on the patient's age. Thus, we cover renal denervation, pulmonary artery denervation, baroreceptor activation therapy, vagus nerve stimulation, spinal cord stimulation, ganglionated plexi ablation for the management of arterial and pulmonary hypertension, heart failure, angina and arrhythmias. The results of many clinical studies appeared to be unconvincing. In view of the low rate of positive findings in clinical studies incorporating neuromodulation approaches, we suggest the underestimation of advanced age as a potential contributing factor to poorer response. Analysis of outcomes between different age groups in clinical trials may shed more light on the true effects of neuromodulation when neutral/ambiguous results are obtained. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16715411
Volume :
19
Issue :
11
Database :
Complementary Index
Journal :
Journal of Geriatric Cardiology
Publication Type :
Academic Journal
Accession number :
161261222
Full Text :
https://doi.org/10.11909/j.issn.1671-5411.2022.11.003