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Analysis of selected genetic variants in psoriasis susceptibility and response to treatment.
- Source :
- Advances in Dermatology & Allergology / Postępy Dermatologii i Alergologii; 2022, Vol. 39 Issue 5, p934-939, 6p
- Publication Year :
- 2022
-
Abstract
- Introduction: Aetiology of psoriasis is complex with risk factors involving both environmental triggers and genetic background. Although the best characterized genetic risk factor for psoriasis is HLA-C*06 allele, a number of other variants were associated with the disease. Aim: In the current paper we have conducted a confirmation study for SNPs located in 9 gene regions in a casecontrol analysis of 507 psoriatic patients and 396 controls from the Polish population. Material and methods: Subsequently the impact of genetic variants on response to topical and NB-UVB therapy (reduction in the Psoriasis Area and Severity Index) was analysed. Results: Significant differences in genotype and/or allelic frequency were observed for the following SNPs: rs33980500 (TRAF3IP2), rs582757 (TNFAIP3I), rs12188300 (IL12B), rs28998802 (NOS2), and rs2233278 (TNIP1). None of the genetic factors was associated with treatment outcome. Conclusions: Although the genetic variants have an impact on the disease risk, they are unlikely to be useful in personalization of topical therapy. [ABSTRACT FROM AUTHOR]
- Subjects :
- ETIOLOGY of diseases
PSORIASIS
GENOTYPES
ALLELES
SINGLE nucleotide polymorphisms
Subjects
Details
- Language :
- English
- ISSN :
- 1642395X
- Volume :
- 39
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Advances in Dermatology & Allergology / Postępy Dermatologii i Alergologii
- Publication Type :
- Academic Journal
- Accession number :
- 161223059
- Full Text :
- https://doi.org/10.5114/ada.2022.120885