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Techno-Economic Evaluation of Novel SARS-CoV-2 Vaccine Manufacturing in the Insect Cell Baculovirus Platform.
- Source :
- International Journal of Technology; 2022, Vol. 13 Issue 8, p1630-1639, 10p
- Publication Year :
- 2022
-
Abstract
- The need to increase the COVID-19 vaccine manufacturing capacity at low to middleincome countries (LMIC) led to a growing focus on Novavax (NVX-CoV2373), a thermostable protein subunit vaccine manufactured using a baculovirus and insect cell system (BICS) platform. This study aimed to conduct a techno-economic analysis to assess the BICS platform of vaccine manufacturing and compare it to the mRNA and the saRNA platform. The data from the Novavax patent for the COVID-19 vaccine formulation and the manufacturing steps were used to simulate the BICS vaccine production in SuperPro Designer. From the techno-economic analysis, the productivity of all platforms was compared in terms of doses/day per L production scale. The saRNA platform’s productivity is about 1,000-fold of the BICS platform and 20-fold of the mRNA platform. BICS is a feasible option for LMIC to produce vaccines because the cost per dose is like the saRNA platform, while the mRNA platform’s cost per dose is 7 times higher than the BICS and saRNA platforms. However, further optimization is necessary to improve the productivity of the BICS platform to match saRNA’s platform. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20869614
- Volume :
- 13
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- International Journal of Technology
- Publication Type :
- Academic Journal
- Accession number :
- 161146365
- Full Text :
- https://doi.org/10.14716/ijtech.v13i8.6139