Association of admission serum levels of neurofilament light chain and in-hospital mortality in geriatric patients with COVID-19.

On the other hand, Hermansson et al. reported that plasma NfL did not correlate with serum creatinine among patients infected with HIV with a mean age of 40 years, suggesting that the relationship between blood NfL and renal function becomes more evident among older adults [[5]]. Here, we assessed admission levels of serum NfL (sNfL) in geriatric patients with COVID-19 with the aim to evaluate the ability of circulating NfL to improve COVID-19 mortality prediction alone and/or in association with other demographic, biochemical, and molecular circulating biomarkers. The minimum number of days for which patients in the recovered group remained hospitalized was one day, while the maximum hospital stay was 53 days for survived patients and 56 days for deceased patients. In conclusion, serum NfL could be associated with severe outcomes in geriatric patients affected by COVID-19, even if caution should be used when interpreting these findings in patients with impaired renal function. [Extracted from the article]