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T-- and B--lymphocyte subpopulations in the tropical splenomegaly syndrome (TSS).
- Source :
- Clinical & Experimental Immunology; Aug1978, Vol. 33 Issue 2, p239-243, 5p
- Publication Year :
- 1978
-
Abstract
- Lymphocyte subpopulations in thirty-nine patients with the tropical splenomegaly syndrome (TSS) were studied using the E-rosette, EAC rosette and direct immunofluorescent staining techniques. In the peripheral blood a decrease in the percentage of T-lymphocytes was found which was accompanied by an increase in the percentage and number of B-lymphocytes. These abnormalities reverted towards normal on treatment. Splenic aspirates contained an increased proportion of T-lymphocytes. The relative T-cell lymphopenia in TSS is probably due to specific trapping or non-specific sequestration of lymphocytes in the liver and spleen. B-cell lymphocytosis is probably due to persistent antigenic or mitogenic stimulation by malaria. [ABSTRACT FROM AUTHOR]
- Subjects :
- SYNDROMES
PROTOZOAN diseases
LYMPHOCYTES
B cells
T cells
MITOGENS
IMMUNOFLUORESCENCE
Subjects
Details
- Language :
- English
- ISSN :
- 00099104
- Volume :
- 33
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Clinical & Experimental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16110974