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A combination of hepatic encephalopathy and body mass index was associated with the point of no return for improving liver functional reserve after sofosbuvir/velpatasvir treatment in patients with hepatitis C virus‐related decompensated cirrhosis
- Source :
- Hepatology Research; Jan2023, Vol. 53 Issue 1, p26-34, 9p
- Publication Year :
- 2023
-
Abstract
- Aims: The real‐world efficacy of sofosbuvir/velpatasvir treatment for patients with hepatitis C virus‐related decompensated cirrhosis is unclear. We aimed to identify factors that improve liver functional reserve after treatment. Methods: This was a multicenter retrospective study of 12‐week sofosbuvir/velpatasvir treatment. A total of 48 patients with Child–Pugh (CP) class B or C were enrolled at 11 institutions. We evaluated changes in liver functional reserve at 24 weeks post‐treatment. Results: At baseline, 40 and eight patients were CP class B and C, respectively. The overall rate of sustained virologic response 12 weeks post‐treatment was 95.8% (46/48). Serum albumin, alanine aminotransferase and α‐fetoprotein levels, and the FIB‐4 index were significantly improved post‐treatment (P < 0.05). Among patients who achieved sustained virologic response 12 weeks post‐treatment, those with CP class A increased from 0 to 24 patients (56%) at 24 weeks post‐treatment. In multivariate analysis, body mass index (BMI) ≥25 was an independent factor that inhibited CP class improvement (P < 0.05). In decision tree analysis, after treatment, the initial divergent variable for CP class improvement was hepatic encephalopathy, followed by serum sodium level and BMI. Conclusion: Sofosbuvir/velpatasvir treatment improved the liver functional reserve in patients with hepatitis C virus‐related decompensated cirrhosis at 24 weeks post‐treatment. However, BMI ≥25 inhibited improvement in CP class. Additionally, decision tree analysis revealed that a combination of hepatic encephalopathy, serum sodium levels, and BMI were diversity profiles associated with no improvement in liver functional reserve after the treatment. [ABSTRACT FROM AUTHOR]
- Subjects :
- HEPATIC encephalopathy
BODY mass index
HEPATITIS
CIRRHOSIS of the liver
SOFOSBUVIR
Subjects
Details
- Language :
- English
- ISSN :
- 13866346
- Volume :
- 53
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Hepatology Research
- Publication Type :
- Academic Journal
- Accession number :
- 161085429
- Full Text :
- https://doi.org/10.1111/hepr.13837