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Detection and Molecular Characterization of Canine Distemper Virus in Wildlife from Northern Italy.
- Source :
- Pathogens; Dec2022, Vol. 11 Issue 12, p1557, 11p
- Publication Year :
- 2022
-
Abstract
- Canine distemper virus (CDV) is a fatal, highly contagious disease found in wild and domestic carnivores. Several outbreaks have occurred in wildlife in Italy in recent years. This study aims to detect CDV in wildlife following the increasing mortality of foxes (Vulpes vulpes) in the Emilia-Romagna region (northern Italy) observed in 2021. Sixty-seven foxes and one badger (Meles meles) were subjected to necropsy followed by histological examination and were analyzed with molecular techniques to detect the presence of CDV. Of the tested animals, 16% (nine foxes and one badger) were positive for CDV. Phylogenetic analysis showed two different lineages based on complete H gene sequences. The Europe/South America-1 lineage was detected in one fox from Modena, which resembled the CDV variant associated with a previous outbreak in northern Italy in 2018, while the European Wildlife lineage was detected in animals from the Rimini province. Amino acid analysis highlighted a Y549H mutation in all sequences collected, which is commonly associated with increased virulence. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20760817
- Volume :
- 11
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Pathogens
- Publication Type :
- Academic Journal
- Accession number :
- 161039817
- Full Text :
- https://doi.org/10.3390/pathogens11121557