Microwave Assisted, H3PW12O40 Mediated Green Synthesis, Crystal Structure, in-Vitro Anti-Inflammatory and Anti-Oxidant Investigation of Enaminoketones.

A simple microwave assisted tungstophosphoric acid (H₃PW₁₂O₄₀) catalyzed protocol was employed for the synthesis of versatile enaminoketones. The developed synthetic procedure is green, efficient and environmentally benign. Using this method, a series of enaminoketones were prepared from the condensation of dimedone and various amines. Further, the synthesized enaminoketones were evaluated for in-vitro anti-inflammatory activity by membrane stabilization method and anti-oxidant efficacy by radical scavenging method. The synthesized enaminoketones 3c, 3b and 3b, 3f showed reasonable anti-inflammatory as well as anti-oxidant activities respectively. [ABSTRACT FROM AUTHOR]